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導讀:威而鋼(Viagra)是一種廣泛使用的處方藥物,用於治療男性勃起功能障礙(ED)。臺北醫學大學附設醫院泌尿科主治醫師-陳偉傑指出:儘管威而鋼是治療陽痿的特效藥,但在使用安全方面至今仍有大部分民眾沒有完整全面的瞭解。
例如無論男女,大部分人都認為飲酒能一定程度上增加性生活的品質。甚至有不少男性認為在服用威而鋼前後飲酒,能進一步有效的提升性功能,這不光是一種錯誤的行為,更可能會導致受到負面傷害。對此在本文我們大樹藥局(https://bigtree19.com)將邀請陳偉傑醫師為我們講述,威而鋼與酒精之間的關聯相關內容,並為安全使用威而鋼作出指導建議。
酒精對威而鋼的影響
威而鋼作為一種磷酸二酯酶-5(PDE5)抑制劑,能夠通過增加血液流入男性生殖器官,從而幫助改善勃起功能障礙。酒精不光會對威而鋼形成交互作用,更會對身體各個系統帶來負面影響,包括中樞神經系統、血液循環系統、代謝系統等。
酒精對中樞神經系統、血液循環、身體代謝的影響
酒精對中樞神經系統的影響:
- 抑制神經傳遞,導致中樞神經系統活動減慢。
- 影響注意力和反應能力,使人感到困倦、反應遲鈍和協調不佳。
- 引起情緒和行為變化,如情緒波動和冒險行為增加。
酒精對血液循環的影響:
- 血管擴張,造成血管舒張和肌肉松弛。
- 血壓變化,可能導致短期血壓升高和長期慢性高血壓。
- 影響血液凝固,增加出血風險。
酒精對身體代謝的影響:
- 增加肝臟負擔,可能導致肝臟疾病和損害。
- 干擾糖代謝,導致血糖水平異常,增加糖尿病風險。
- 減少營養吸收,可能導致營養不良和營養素不足。
酒精與威而鋼的交互作用關係
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酒精和威而鋼都對身體產生影響,如果同時存在體內會引起一定的交互作用,這視乎酒精攝入量與威而鋼用藥量,以下是一些關於酒精和威而鋼交互作用的要點:
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相互增強的血管擴張作用:酒精和威而鋼都可以引起血管擴張,這可能導致血壓降低。當酒精和威而鋼同時使用時,它們的血管擴張作用可能相互增強,進一步降低血壓。這可能對某些人,特別是那些已經患有低血壓或正在服用降壓藥物的人,產生不良影響。
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減弱威而鋼的效果:酒精可能減弱威而鋼的效果,威而鋼通常被用來治療勃起功能障礙,它可以幫助增加血流到男性生殖器官,從而促進勃起。然而酒精攝入可能導致血管收縮,這可能降低威而鋼的效果,使其難以實現預期的勃起。
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增加副作用風險:同時攝入酒精和威而鋼可能增加副作用的風險,酒精本身就具有某些副作用,如頭暈、噁心、心跳加快等。當與威而鋼一起使用時,這些副作用可能會更加明顯和不舒適。此外酒精可能增加威而鋼的副作用,如頭痛、面紅和消化不良等。
飲酒前後服用威而鋼可能造成的風險
在飲酒前後服用威而鋼,可能造成的身體風險包括導致藥物效果不佳甚至失效、加劇威而鋼副作用、對血壓產生負面影響等。這些風險問題都會給身體健康帶來一定隱患,視乎飲酒量或威而鋼攝入量的多寡,在嚴重情況下有致死可能。
可能導致藥效不佳或失效
酒精攝入可能降低威而鋼在消化系統中的吸收率,因為酒精會刺激胃酸分泌,並導致消化不良。這可能影響威而鋼的吸收,使其在體內的效果降低。酒精可以對中樞神經系統產生抑制作用,這可能影響威而鋼的起效時間。
這意味著你可能需要更長的時間才能感受到威而鋼的效果,甚至可能需要更高的劑量才能達到預期的效果。酒精還會刺激肝臟代謝酶的活性,使其更快地代謝藥物。這可能導致威而鋼在體內的濃度降低,使其效果減弱甚至失效。
可能加劇威而鋼副作用
酒精和威而鋼都可以對心血管系統產生影響,同時使用時酒精可能加劇威而鋼的心血管副作用,如心悸、心律不整和血壓變化,威而鋼嚴重副作用除了會帶來不適,更會造成一定健康風險問題,尤其對本身存在心血管疾病的患者更危險;酒精和威而鋼都可能對消化系統產生副作用,可能出現消化不良、胃灼熱、腹痛等不適感;
對中樞神經系統而言,如果同時使用可能增加頭痛、頭暈、嗜睡等中樞神經系統副作用的風險。這些副作用表現程度會隨著酒精或威而鋼劑量的攝入增加而增加,並給身體帶來極大的不適感,嚴重時甚至有致死可能。
可能對血壓產生負面影響
威而鋼與酒精都會導致血管擴張,這可能導致血壓下降。也可能會刺激交感神經系統,導致血壓上升。當與威而鋼一起使用時,這種相反的效應可能導致血壓不穩定,增加血壓升高的風險。
如果本身就患有高血壓,同時攝入酒精和威而鋼可能加劇現有的高血壓問題。酒精和威而鋼都可以對血壓產生影響,同時使用可能使血壓難以控制,增加心血管疾病的風險。
安全使用建議
想要安全的使用威而鋼,咨詢專業的醫師或藥師非常有必要。他們可以評估你的身體狀況,了解你是否適合使用這種藥物,以及建議正確的劑量和使用方式。並且咨詢專業醫師或藥師還能瞭解,會與威而鋼產生交互作用的食物與藥物禁忌,這能進一步確保你用藥的安全性。
另外對於威而鋼的用法用量也要清楚了解,雖然不同的陽痿患者所用劑量會有不同,但這並不意味著可以超過安全劑量的使用。請始終在專業醫師或藥師的指導下使用威而鋼,以確保治療的安全與有效。
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時間間隔建議
如果無可避免的飲酒之後需要服用威而鋼,兩者間至少需要間隔8小時以上才比較不會相互帶來影響。但鑒於每個人對酒精和威而鋼的代謝速度不同,因此時間間隔的建議僅作為一般參考。根據個人的體驗和醫生的指導,你可以調整時間間隔,以確保安全和有效的使用。
總結
雖然有些人可能在同時飲酒與服用威而鋼時並未遇到問題,但酒精和威而鋼的交互作用可能對身體產生不利的影響。酒精對中樞神經系統、血液循環和身體代謝都有影響,同時攝入可能增加風險。為了確保安全和有效的使用威而鋼,建議限制酒精攝入量,適當控制時間間隔,並根據醫生的建議適應自己的使用方式。
隨著生活壓力和疾病的增加,許多男性在性方面遇到了困難。威而鋼是一種廣泛使用的藥物,可以幫助男性解決勃起障礙問題。威而鋼在使用時需要注意一些禁忌事項,以避免副作用和危險。在本篇文章中,大樹藥局(https://bigtree19.com)將會介紹服用威而鋼的禁忌事項,讓患者了解哪些人士禁止使用該藥物,以及哪些情況下威而鋼與其他藥物、食物有禁忌。了解這些信息可以幫助患者更加安全地使用威而鋼,同時提高其療效。
威而鋼的藥物、食物以及禁忌人群
下面將詳細介紹服用威而鋼時需要注意的藥物禁忌、食物禁忌以及禁忌人群,幫助患者避免可能帶來的風險。如果患者正考慮使用威而鋼,請務必仔細下面內容,並在使用之前咨詢醫師或藥師的意見:
威而鋼藥物禁忌
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對於正在服用某些藥物的人士,使用威而鋼可能會導致嚴重的副作用。以下是使用威而鋼時需要注意的一些藥物禁忌:
硝酸藥物
硝酸藥物是治療心臟病和高血壓的常用藥物,但是這些藥物不能與威而鋼一起使用。因為硝酸藥物和威而鋼一起使用可能會導致嚴重的降血壓,甚至可能導致死亡。
α-受體阻滯劑
α-受體阻滯劑是治療高血壓和攝護腺增生的藥物,這些藥物和威而鋼一起使用可能會增加低血壓的風險。
CYP3A4 抑制劑
CYP3A4 抑制劑是一種常見的藥物,可以治療多種疾病,如高血壓、高膽固醇等。然而,這些藥物可能會干擾威而鋼的代謝,增加副作用的風險。
血液稀釋劑
血液稀釋劑是用來防止血栓形成的藥物。當這些藥物和威而鋼一起使用時,可能會增加出血的風險。
不能與威而鋼併服的15種藥物
以下是與威而鋼同服可能會導致嚴重副作用的15種藥物:
- 硝酸甘油:治療心絞痛和心血管疾病的藥物。
- 硝酸異山梨酯:治療心絞痛和心血管疾病的藥物。
- 鈉硝酸:治療心臟病和高血壓的藥物。
- 亞硝酸異戊酯:治療心絞痛和心血管疾病的藥物。
- 伊索吉布:治療肺動脈高壓症的藥物。
- 利血平:治療高血壓和心臟病的藥物。
- 氨醯心安:治療心絞痛和高血壓的藥物。
- 氨醯異卓:治療心臟病和高血壓的藥物。
- 地高辛:治療心臟病的藥物。
- 紅黴素:一種抗生素。
- 瑞德西韋:治療COVID-19的藥物。
- 潑尼松:一種類固醇激素,用於治療炎症和免疫系統問題。
- 阿司匹林:一種非甾體消炎藥,用於治療疼痛和炎症。
- 他汀類藥物:用於治療高膽固醇和心血管疾病的藥物。
- 二甲雙胍:治療糖尿病的藥物。
如果患者正在服用以上任何一種藥物,應在使用威而鋼之前告知醫師或藥師,以便他們決定是否適合服用威而鋼或調整用藥劑量。
威而鋼食物禁忌
除了藥物禁忌,還有一些食物禁忌需要注意,避免這些食物可以減少威而鋼的副作用,以下是一些需要注意的食物禁忌:
酒精
酒精是一種神經系統抑制劑,與威而鋼一起使用可能會增加副作用的風險,尤其是降低血壓的風險。因此,使用威而鋼期間應該避免飲酒。
高脂肪食物
食用高脂肪食物會增加威而鋼的代謝時間,從而增加副作用的風險。因此,應避免食用高脂肪食物,特別是在使用威而鋼之前。
葡萄柚和柚子
葡萄柚和柚子中含有一些成分,可能會抑制威而鋼的代謝,從而增加副作用的風險。因此,在使用威而鋼期間應避免食用葡萄柚和柚子。
咖啡因
咖啡因是一種中樞神經興奮劑,與威而鋼一起使用可能會增加副作用的風險。因此,在使用威而鋼期間應該限制咖啡因的攝入。
威而鋼禁忌人群
除了藥物和食物禁忌外,還有一些禁忌人群需要注意,這些人群使用威而鋼可能會增加副作用的風險,以下是一些需要注意的禁忌人群:
心臟病患者
心臟病患者使用威而鋼可能會增加心臟病發作的風險,尤其是那些正在服用硝酸甘油等硝酸鹽藥物的患者。因此,這些患者應該在使用威而鋼之前咨詢醫師的意見。
低血壓患者
威而鋼可能會降低血壓,因此低血壓患者使用威而鋼可能會增加低血壓的風險。因此,這些患者應該在使用威而鋼之前咨詢醫生的意見。
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肝臟或腎臟疾病患者
肝臟或腎臟疾病患者可能會影響威而鋼的代謝和排洩,從而增加副作用的風險。因此,這些患者應該在使用威而鋼之前咨詢醫生的意見。
青少年
由於青少年的生理發育尚未完成,因此並不建議未滿18歲的青少年服用威而鋼。
文章結論
在本文中,我們詳細介紹了使用威而鋼時需要注意的藥物禁忌、食物禁忌以及禁忌人群。這些禁忌可能會增加副作用的風險,因此使用威而鋼之前需要謹慎評估風險和益處,遵循醫師或藥師的建議,以避免可能帶來的風險。
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威而鋼是一種有效的治療男性勃起功能障礙的藥物,但是需要在合適的情況下使用。在使用之前,請務必向醫師或藥師咨詢意見,並告知專業人員有關自己的所有健康狀況、藥物和食物過敏等信息。這樣可以減少副作用的風險,從而提高治療的效果。
肺動脈高壓是一種罕見的、進展迅速的疾病，其特征是肺小動脈收縮和肺循環血壓升高。這會阻止血液流向肺部，導致心力衰竭。患者通常要承受每天服用大量藥物的負擔。馬昔騰坦和他達拉非是該病一線治療的兩種藥物，將這兩種藥物合並在一種每日一次的單一口服療法中，可以減輕護理負擔。
近日，美國FDA批準了Opsynvi(macitentan/tadalafil，馬昔騰坦/他達拉非)，用於長期治療WHO功能分級（FC）II-III的肺動脈高壓（PAH，WHO I組）成人患者。預計該藥物將於4月中旬在美國上市。
II級患者在休息時沒有任何癥狀，但在爬樓梯等正常活動時感到不舒服和呼吸短促。
III級患者的活動在嘗試做家務等事情時會因呼吸短促、疲勞或近乎昏厥而受到極大限制。
由強生公司研發的Opsynvi是一種內皮素受體拮抗劑馬昔騰坦(macitentan)和磷酸二酯酶5(PDE5)抑制劑他達拉非(tadalafil)的單片組合。其兩種成分均適用於治療肺動脈高壓患者。馬昔騰坦可降低臨床惡化事件和住院治療的風險，而他達拉非可提高運動能力。
Opsynvi是肺動脈高壓患者的首個且是目前唯一一個每日一次的單片聯合療法。該治療組合於2021年首次獲得批準，當時加拿大衛生部批準將其作為已經單獨服用這兩種療法的肺動脈高壓患者的替代藥物。阿根廷也已批準該適應癥。
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Opsynvi的批準基於3A期DUE試驗(NCT03904693)的數據，該試驗比較了Opsynvi與馬昔騰坦或他達拉非單藥治療在187名未曾接受治療或使用穩定劑量的內皮素受體拮抗劑或PDE5抑制劑至少3個月的肺動脈高壓患者（WHO FC II-III）中的療效和安全性。
肺血管阻力(PVR)至少240dyn·s/cm⁵的患者被隨機分配接受Opsynvi(n=108)、馬昔騰坦10mg(n=35)或他達拉非40mg(n=44)每日一次。
主要終點是治療開始後16周測量的肺血管阻力（表示為幾何平均值與起始的比率）。研究結果顯示，與馬昔騰坦和他達拉非相比，Opsynvi治療導致PVR顯著降低，具有統計學意義。
與馬昔騰坦的治療效果比：-29%[95%CI，-39%，-18%；P<0.0001]。
與他達拉非的治療效果比：-28%[95%CI,-36%,-20%]；P<0.0001]。
這種療效在未接受過治療的患者以及既往接受過內皮素受體拮抗劑或PDE5抑制劑的患者中是一致的。
印度神油ptt Climax for men印度神油評測分享
Opsynvi最常見的不良反應是水腫/液體瀦留、貧血和頭痛/偏頭痛。Opsynvi的處方信息包括有關胚胎-胎兒毒性風險的黑框警告。對於女性患者，Opsynvi隻能通過一項名為“含馬昔騰坦藥品風險評估和緩解策略”(REMS)的限制計劃獲得。
參考來源：‘U.S. FDA Approves OPSYNVI® (macitentan and tadalafil) as the First and Only Once-Daily Single-Tablet Combination Therapy for Patients with Pulmonary Arterial Hypertension (PAH)’，新聞稿。Johnson & Johnson；2024年3月22日發佈。
註：本文旨在介紹醫藥健康研究，不作任何用藥依據，具體用藥指引，請咨詢主治醫師。
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